Publications

Preprints

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

Sams EI, Feist VK, Gray EM, George SS, Antony C, Henrich JA, Alrobaire K, Hung PJ, Gonskikh Y, Moore SL, Ghatak D, Wald J, Dunagin MC, Shah N, Hintzen JCJ, Wang Z, Erlitzki N, Burslem GM, Raj A, Bowman RL, Liu KF, Tong W, Signer RAJ, Paralkar VR

bioRxiv | updated May 2026 | Article | GEO Datasets

Publications

Ribosomal RNA transcription in normal and leukemic hematopoiesis

Henrich JA*, Sams EI*, Paralkar VR

Current Topics in Developmental Biology | Review | Sep 2026 | Article | *equal contribution

Genomic Approaches to Hematology

Hung PJ*, Bhansali RS*, Paralkar VR

Hematology: Basic Principles and Practice | Textbook chapter | 2026 | in press | *equal contribution

Transcriptome and chromatin accessibility divergence during differentiation of a bipotential progenitor cell population to erythroblasts and megakaryocytes

Mishra T, Giardine BM, Morrissey CS, Keller CA, Heuston EF, Anderson SM, Paralkar VR, Pimkin M, Weiss MJ, Bodine DM, Hardison RC

Journal of Biological Chemistry | Oct 2025 | Article

Defining the impact of rRNA processing on nucleolar organization and function

Mendoza-Figueroa MS, Lavorando E, Gonskikh Y, Antony C, Elashal H, Chen AY, Tang H-Y, Carone D, Paralkar VR, Liu KF

bioRxiv | Oct 2025 | Article

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness

Pawar AS, Somers P, Alex A, Grana J, Feist VK, George SS, Jalnapurkar SS, Antony C, Verner R, White-Brown SK, Khera M, Mendoza-Figueroa MS, Liu KF, Morrissette JJD, Gurbuxani S, Paralkar VR

Genes and Development | Jul 2025 | Article | Commentary | GEO Datasets

Evolving racial/ethnic disparities in AML survival in the novel therapy era

Wang X, Gimotty PA, Matthews AH, Mamtani R, Luger SM, Hexner EO, Babushok DV, McCurdy SR, Frey NV, Bruno XJ, Gill S, Martin ME, Paralkar VR, Maillard I, Porter DL, Loren AW, Perl AE, Pratz KW, Getz KD, Lai C

Blood Advances | Feb 2025 | Article

Tumor Lysis Syndrome in Acute Myeloid Leukemia Patients Treated With a Venetoclax Based Regimen

Rowe M, Babushok D, Carroll M, Carulli A, Frey N, Gill S, Hexner E, Hirsh R, Hossain N, Lai C, Loren A, Luger S, Maillard I, McCurdy S, Matthews A, Martin ME, Paralkar VR, Perl A, Porter D, Pratz K, Stadtmauer E, Bruno XJ

European Journal of Haematology | Dec 2024 | Article

Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models

Rondeau V, Berman JM, Ling Y, O’Brien C, Culp-Hill R, Reisz JA, Wunderlich M, Chueh Y, Jiménez-Camacho KE, Sexton C, Carter KM, Stillwell C, St-Germain J, Yendi D, Gupta A, Shi M, Bourdine A, Paralkar VR, Jahangiri S, Hope KJ, Tikhonova AN, Arruda A, Minden MD, Raught B, D’Alessandro A, Jones CL

Science Translational Medicine | Sep 2024 | Article

PHF6 suppresses self-renewal of leukemic stem cells in AML

Jalnapurkar SS*, Pawar AS*, George SS, Antony C, Somers P, Grana J, Feist VK, Gurbuxani S, Paralkar VR

Leukemia | Jul 2024 | Article | GEO Datasets | *equal contribution

Transcription factor regulation of ribosomal RNA in hematopoiesis

Paralkar VR

Current Opinion in Hematology | Review | Apr 2024 | Article

FISH-Flow to quantify nascent and mature ribosomal RNA in mouse and human cells

Antony C, Somers P, Gray EM, Pimkin M, Paralkar VR

STAR Protocols | Jul 2023 | Article

Real-world effectiveness of intensive chemotherapy with 7&3 versus venetoclax and hypomethylating agent in acute myeloid leukemia

Matthews AH, Perl AE, Luger SM, Gill SI, Lai C, Porter DL, Skuli S, Bruno XJ, Carroll MP, Freyer CW, Carulli A, Babushok DV, Frey NV, Hexner EO, Martin ME, McCurdy SR, Stadtmauer EA, Loren AW, Paralkar VR, Maillard IP, Pratz KW

American Journal of Hematology | Jun 2023 | Article

Construction and validation of customized genomes for human and mouse ribosomal DNA mapping

George SS, Pimkin M, Paralkar VR

Journal of Biological Chemistry | Editors’ Pick | May 2023 | Article | GitHub Genomes and Tracks

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors

Harada T, Perez MW, Kalfon J, Braes FD, Batley R, Eagle K, Nabet B, Leifer B, Kruell J, Paralkar VR, Stegmaier K, Koehler AN, Orkin SH, Pimkin M

bioRxiv | Apr 2023 | Article

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

Harada T, Kalfon J, Perez MW, Eagle K, Braes FD, Batley R, Heshmati Y, Ferrucio JX, Ewers J, Mehta S, Kossenkov A, Ellegast JM, Bowker A, Wickramasinghe J, Nabet B, Paralkar VR, Dharia NV, Stegmaier K, Orkin SH, Pimkin M

bioRxiv | Mar 2023 | Article

Control of ribosomal RNA synthesis by hematopoietic transcription factors

Antony C, George SS, Blum J, Somers P, Thorsheim CL, Wu-Corts DJ, Ai Y, Gao L, Lv K, Tremblay MG, Moss T, Tan K, Wilusz JE, Ganley ARD, Pimkin M, Paralkar VR

Molecular Cell | Oct 2022 | Article | GEO Datasets

Transcriptional Plasticity Drives Leukemia Immune Escape

Eagle K, Harada T, Kalfon J, Perez MW, Heshmati Y, Ewers J, Koren JV, Dempster JM, Kugener G, Paralkar VR, Lin CY, Dharia NV, Stegmaier K, Orkin SH*, Pimkin M*

Blood Cancer Discovery | Sep 2022 | Article | *equal contribution

Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia

Matthews AH, Perl AE, Luger SM, Loren AW, Gill SI, Porter DL, Babushok DV, Maillard IP, Carroll MP, Frey NV, Hexner EO, Martin ME, McCurdy SR, Stadtmauer EA, Paralkar VR, Bruno XJ, Hwang WT, Margolis D, Pratz KW

Blood Advances | Jul 2022 | Article

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabič Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH*, Pimkin M*

Genes and Development | Mar 2022 | Article | *equal contribution

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, Cheng Y, Pellegrino S, Warren AJ, Paralkar VR, Tong W

Cell Stem Cell | Jul 2021 | Article

Regulation of gene expression by miR-144/451 during mouse erythropoiesis

Xu P, Palmer LE, Lechauve C, Zhao G, Yao Y, Luan J, Vourekas A, Tan H, Peng J, Schuetz JD, Mourelatos Z, Wu G, Weiss MJ*, Paralkar VR*

Blood | Jun 2019 | Article | GEO Datasets | *equal contribution

Nonspecific inhibition of erythropoiesis by short hairpin RNAs

Traxler EA, Thom CS, Yao Y, Paralkar V, Weiss MJ

Blood | Jun 2018 | Article

Unlinking an lncRNA from Its Associated cis Element

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ.

Molecular Cell | Apr 2016 | Article | Commentary | GEO Datasets

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development

Paralkar VR, Mishra T, Luan J, Yao Y, Kossenkov AV, Anderson SM, Dunagin M, Pimkin M, Gore M, Sun D, Konuthula N, Raj A, An X, Mohandas N, Bodine DM, Hardison RC, Weiss MJ

Blood | Mar 2014 | Article | GEO Datasets

Long noncoding RNAs in biology and hematopoiesis

Paralkar VR, Weiss MJ

Blood | Review | Jun 2013 | Article

Allogeneic hematopoietic SCT for primary cutaneous T cell lymphomas

Paralkar VR, Nasta SD, Morrissey K, Smith J, Vassilev P, Martin ME, Goldstein SC, Loren A, Rook AH, Kim EJ, Porter DL

Bone Marrow Transplantation | Jul 2012 | Article

A new ‘Linc’ between noncoding RNAs and blood development

Paralkar VR, Weiss MJ

Genes and Development | Review | Dec 2011 | Article

Severe eosinophilia as a manifestation of acute graft-versus-host disease

Paralkar VR, Goradia A, Luger SM, Loren AW

Oncology | Sep 2008 | Article

Population characteristics and prognostic factors in metastatic non-small-cell lung cancer: a Fox Chase Cancer Center retrospective

Paralkar VR, Li T, Langer CJ

Clinical Lung Cancer | Mar 2008 | Article

Worlds Apart – Tuberculosis in India and the United States

Paralkar V

New England Journal of Medicine | Commentary | Mar 2008 | Article