Paralkar Lab, ribosome biogenesis, ribosome hematopoiesis, leukemia, transcription, epigenetics

Preprints

PHF6 suppresses self-renewal of leukemic stem cells in AML

Jalnapurkar SS, Pawar A, George SS, Antony C, Grana J, Gurbuxani S, Paralkar VR
bioRxiv | Jan 2024 | Article

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors

Harada T, Perez MW, Kalfon J, Braes FD, Batley R, Eagle K, Nabet B, Leifer B, Kruell J, Paralkar VR, Stegmaier K, Koehler AN, Orkin SH, Pimkin M
bioRxiv | Apr 2023 | Article

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

Harada T, Kalfon J, Perez MW, Eagle K, Braes FD, Batley R, Heshmati Y, Ferrucio JX, Ewers J, Mehta S, Kossenkov A, Ellegast JM, Bowker A, Wickramasinghe J, Nabet B, Paralkar VR, Dharia NV, Stegmaier K, Orkin SH, Pimkin M
bioRxiv | Mar 2023 | Article

Publications

Transcription factor regulation of ribosomal RNA in hematopoiesis

Paralkar VR
Current Opinion in Hematology | Apr 2024 | Article

FISH-Flow to quantify nascent and mature ribosomal RNA in mouse and human cells

Antony C, Somers P, Gray EM, Pimkin M, Paralkar VR
STAR Protocols | Jul 2023 | Article

Real-world effectiveness of intensive chemotherapy with 7&3 versus venetoclax and hypomethylating agent in acute myeloid leukemia

Matthews AH, Perl AE, Luger SM, Gill SI, Lai C, Porter DL, Skuli S, Bruno XJ, Carroll MP, Freyer CW, Carulli A, Babushok DV, Frey NV, Hexner EO, Martin ME, McCurdy SR, Stadtmauer EA, Loren AW, Paralkar VR, Maillard IP, Pratz KW
American Journal of Hematology | Jun 2023 | Article

Construction and validation of customized genomes for human and mouse ribosomal DNA mapping

George SS, Pimkin M, Paralkar VR
Journal of Biological Chemistry | Editors’ Pick | May 2023 | Article | GitHub Genomes and Tracks

Control of ribosomal RNA synthesis by hematopoietic transcription factors

Antony C, George SS, Blum J, Somers P, Thorsheim CL, Wu-Corts DJ, Ai Y, Gao L, Lv K, Tremblay MG, Moss T, Tan K, Wilusz JE, Ganley ARD, Pimkin M, Paralkar VR
Molecular Cell | Oct 2022 | Article | GEO Datasets

Transcriptional Plasticity Drives Leukemia Immune Escape

Eagle K, Harada T, Kalfon J, Perez MW, Heshmati Y, Ewers J, Koren JV, Dempster JM, Kugener G, Paralkar VR, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M
Blood Cancer Discovery | Sep 2022 | Article

Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia

Matthews AH, Perl AE, Luger SM, Loren AW, Gill SI, Porter DL, Babushok DV, Maillard IP, Carroll MP, Frey NV, Hexner EO, Martin ME, McCurdy SR, Stadtmauer EA, Paralkar VR, Bruno XJ, Hwang WT, Margolis D, Pratz KW
Blood Advances | Jul 2022 | Article

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabič Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M
Genes and Development | Mar 2022 | Article

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, Cheng Y, Pellegrino S, Warren AJ, Paralkar VR, Tong W
Cell Stem Cell | Jul 2021 | Article

Regulation of gene expression by miR-144/451 during mouse erythropoiesis

Xu P, Palmer LE, Lechauve C, Zhao G, Yao Y, Luan J, Vourekas A, Tan H, Peng J, Schuetz JD, Mourelatos Z, Wu G, Weiss MJ, Paralkar VR
Blood | Jun 2019 | Article | GEO Datasets

Nonspecific inhibition of erythropoiesis by short hairpin RNAs

Traxler EA, Thom CS, Yao Y, Paralkar V, Weiss MJ
Blood | Jun 2018 | Article

Unlinking an lncRNA from Its Associated cis Element

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ.
Molecular Cell | Apr 2016 | Article | Commentary | GEO Datasets

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development

Paralkar VR, Mishra T, Luan J, Yao Y, Kossenkov AV, Anderson SM, Dunagin M, Pimkin M, Gore M, Sun D, Konuthula N, Raj A, An X, Mohandas N, Bodine DM, Hardison RC, Weiss MJ
Blood | Mar 2014 | Article | GEO Datasets

Long noncoding RNAs in biology and hematopoiesis

Paralkar VR, Weiss MJ
Blood | Jun 2013 | Article

Allogeneic hematopoietic SCT for primary cutaneous T cell lymphomas

Paralkar VR, Nasta SD, Morrissey K, Smith J, Vassilev P, Martin ME, Goldstein SC, Loren A, Rook AH, Kim EJ, Porter DL
Bone Marrow Transplantation | Jul 2012 | Article

A new ‘Linc’ between noncoding RNAs and blood development

Paralkar VR, Weiss MJ
Genes and Development | Dec 2011 | Article

Severe eosinophilia as a manifestation of acute graft-versus-host disease

Paralkar VR, Goradia A, Luger SM, Loren AW
Oncology | Sep 2008 | Article

Population characteristics and prognostic factors in metastatic non-small-cell lung cancer: a Fox Chase Cancer Center retrospective

Paralkar VR, Li T, Langer CJ
Clinical Lung Cancer | Mar 2008 | Article

Worlds Apart – Tuberculosis in India and the United States

Paralkar V
New England Journal of Medicine | Mar 2008 | Article