Paralkar Lab, ribosome biogenesis, ribosome hematopoiesis, leukemia, transcription, epigenetics

Grant from the Abramson Cancer Center

The Paralkar Lab is awarded a Pilot Research Grant by the Abramson Cancer Center to model AML evolution from germline Runx1 mutations. This grant is in collaboration with the laboratory of Nancy Speck, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine.

Grant from National Institutes of Health

Charles Antony, Post-Doctoral Researcher, is awarded a Co-Operative Center for Excellence in Hematology (CCEH) Type B grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) to study transcription factor dynamics and regulation in primary human bone marrow.

Poster presentation at CAMB symposium

Aishwarya Pawar, PhD student, presents a poster at the Cell and Molecular Biology Graduate Group Symposium 2023 on regulation of leukemia stemness by the chromatin factor PHF6.

Equipment award from National Institutes of Health

The Paralkar Lab is awarded an equipment award by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) to purchase a dedicated Sony benchtop SH800 cell flow sorter.

Talk at CAMB Penn Cancer Research Series

Charles Antony, Post-Doctoral Researcher, presents a talk on rRNA regulation in hematopoiesis to the Cell and Molecular Biology Graduate Group at the University of Pennsylvania Perelman School of Medicine.

Poster Presentation at Penn CURF

Aleena Alex, UPenn undergraduate student, presents a poster at the Center for Undergraduate Research and Fellowships (CURF) Fall Research Expo on her work on PHD domain point mutations in chromatin regulators in leukemia.

Poster Presentations at ISEH

Post-Doctoral Researcher Charles Antony and graduate student Aishwarya Pawar present posters of their work on chromatin and rRNA transcription regulation in hematopoiesis and leukemia at the International Society of Experimental Hematology 2023 Annual Meeting in New York.

Talk at FASEB Hematological Malignancies Conference

Vikram Paralkar gives a talk on the role of CEBPA in rRNA transcriptional regulation in hematopoiesis and leukemia at the FASEB Hematological Malignancies Conference at Southbridge, Massachusetts. Many thanks to organizers Britta Will and Alejandro Gutierrez.

Publication in STAR Protocols

Publication of “FISH-Flow to quantify nascent and mature ribosomal RNA in mouse and human cells“ in STAR PROTOCOLS by Charles Antony, Patrick Somers, and Erin Gray in the Paralkar Lab.

Talk at the Penn Epigenetics Institute

Charles Antony, Post-Doctoral Researcher, presents a talk on rDNA and rRNA regulation to the Penn Epigenetics Institute at the University of Pennsylvania Perelman School of Medicine.

Talk at the Fragile Nucleosome Seminar

Vikram Paralkar gives a talk on rRNA transcriptional regulation at the Fragile Nucleosome Seminar series. Many thanks to Ben Martin and team for organizing this amazing forum and series of talks!

Talk at the RNA Polymerases 2023 conference

Vikram Paralkar gives a talk at International Conference on Transcriptional Regulation and Regulation by Archaeal, Plant and Eukaryotic Polymerases at the University of Jaén, Spain. Many thanks to Jorge Perez-Fernandez for the wonderful meeting and hospitality!

Talk at University of Michigan

Vikram Paralkar gives a talk on hematopoietic and leukemic transcriptional regulation to the University of Michigan Division of Hematology-Oncology. Many thanks to Shannon Carty for the invitation!

Talk at CAMB Penn Cancer Research Series

Charles Antony, Post-Doctoral Researcher, presents a talk on rRNA regulation in hematopoiesis and leukemia to the Cell and Molecular Biology Graduate Group at the University of Pennsylvania Perelman School of Medicine.

Talk at CAMB Penn Cancer Research Series

Aishwarya Pawar, PhD student, presents a talk on chromatin regulator mutations in acute myeloid leukemia to the Cell and Molecular Biology Graduate Group at the University of Pennsylvania Perelman School of Medicine.

Poster Presentations at ASH

Post-Doctoral Researchers Sapana Jalnapurkar (ASH Restart Award recipient) and Charles Antony (ASH Scholar Award recipient) present posters of their work on chromatin and rRNA transcription regulation in hematopoiesis and leukemia at the American Society of Hematology 2022 Annual Meeting in New Orleans.

Undergraduate Student Awarded Research Grant

Aleena Alex, UPenn undergraduate student, is awarded the Center for Undergraduate Research and Fellowships (CURF) Award to study PHD domain point mutations in chromatin regulators in leukemia.

Publication in Molecular Cell

Publication of “Control of ribosomal RNA synthesis by hematopoietic transcription factors” in MOLECULAR CELL by Charles Antony, Post-Doctoral Researcher, as first author, and with contributions from Subin George, Justin Blum, Patrick Somers, Chelsea Thorsheim, and Dexter Wu-Corts from the Paralkar Lab.

Graduate Student Awarded Best Poster Presentation

Aishwarya Pawar, PhD student, is awarded the Best Poster Presentation for Cancer Biology at the Cell and Molecular Biology Graduate Group Symposium 2022 for her presentation on chromatin occupancy and regulation by PHF6 in leukemia.

Talks at UPenn Heme Malignancies Research in Progress meeting

Sapana Jalnapurkar, Post-Doctoral Researcher, and Aishwarya Pawar, PhD Student, present talks on work in mouse and human cell line models on the role of the chromatin regulation PHF6 in leukemia at the UPenn Heme Malignancies Research in Progress meeting.

Grant from Abramson Family Cancer Research Institute

The Paralkar Lab is awarded a Pilot Research Grant by the Abramson Family Cancer Research Institute to perform a CRISPR tiling mutagenesis screen to dissect ribosome biogenesis regulation in leukemia. This grant is in collaboration with the laboratory of Junwei Shi, Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine.

Talk at Penn and CHOP Retreat

Vikram Paralkar gives a talk on ribosome biogenesis in leukemia gives a talk at the Penn and CHOP Hematological Malignancies Program Annual Retreat.

Poster Presentations at Penn

Aishwarya Pawar, Ph.D. student, and Charles Antony, Post-Doctoral Researcher, present posters on transcriptional and ribosome biogenesis regulation in hematopoiesis and leukemia at the UPenn Department of Medicine Research Day 2022.

Talk at University of Colorado

Vikram Paralkar visits the University of Colorado Anschutz Medical Campus and gives a talk on ribosomal regulation in hematopoiesis. Much gratitude to Patricia Ernst for the invitation!

Talk at Penn Cell and Developmental Biology Retreat

Charles Antony, Post-Doctoral Researcher, presents a talk on regulation of rRNA transcription by CEBPA at the Cell and Developmental Biology Departmental Retreat for the University of Pennsylvania Perelman School of Medicine.

Talk at University of California, San Diego

Vikram Paralkar pays a virtual visit to the University of California, San Diego (UCSD), and gives a talk to the Division of Regenerative Medicine on transcriptional regulation in hematopoiesis. Many thanks to Rob Signer for the invitation!

Collaborative publication in Genes and Development

Publication by laboratory of Stuart Orkin and Max Pimkin of “A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia” in GENES & DEVELOPMENT, with contribution from Paralkar Lab.

Talks and Poster Presentations at ASH

Vikram Paralkar gives a talk at the Scientific Workshop on Myeloid Development at the American Society of Hematology Annual Meeting 2021. Charles Antony, Post-Doctoral Researcher, and Aishwarya Pawar, PhD Student, present posters on rRNA transcription and chromatin regulation in leukemia.

Talk at ASBMB conference

Vikram Paralkar gives a talk at the American Society for Biochemistry and Molecular Biology (ASBMB) conference on Emerging roles of the nucleolus.

Talk at FASEB meeting

Vikram Paralkar gives a talk on the role of CEBPA in ribosomal RNA regulation at the FASEB Hematological Malignancies Conference.

Collaborative Publication in Cell Stem Cell

Laboratory of Wei Tong, Children’s Hospital of Philadelphia, publishes “HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis” in CELL STEM CELL with contribution from Charles Antony and Vikram Paralkar from the Paralkar Lab.

Poster Presentations at Penn

Charles Antony and Sapana Jalnapurkar, Post-Doctoral Researchers, present posters on ribosomal RNA regulation and leukemia mouse models at the University of Pennsylvania Department of Medicine Research Day 2021.

Talk at Keystone Symposium

Vikram Paralkar gives a talk on the role of transcription factors in regulating ribosomal RNA at the Keystone Symposium on Hematopoiesis.

Grant from National Institutes of Health

The Paralkar Lab is awarded a Co-Operative Center for Excellence in Hematology (CCEH) grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) to model the effect of RUNX1 point mutations on mouse hematopoietic stem and progenitor cells.

Grant from National Institutes of Health

The Paralkar Lab is awarded an R01 grant by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to study the role of the chromatin binding and nucleolar protein PHF6 in the regulation of HSC self-renewal and myeloid differentiation.

Presentations at ASH

Sapana Jalnapurkar and Charles Antony, Post-Doctoral Researchers, present oral talk and poster presentation respectively at the American Society of Hematology Annual Meeting 2020.

Grant from National Institutes of Health

The Paralkar Lab is awarded a MIRA R35 grant by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) to study the regulation of ribosomal RNA transcription in mammalian tissues.

Poster Presentations at Penn

Sapana Jalnapurkar and Charles Antony, Post-Doctoral Researchers, present posters at the University of Pennsylvania Department of Medicine Research Day 2020.

Grant from American Cancer Society

The Paralkar Lab receives funding through the American Cancer Society Institutional Research Grant to study the role of PHF6 in acute myeloid leukemia.

Publication in Blood

The Paralkar Lab publishes “Regulation of gene expression by miR-144/451 during mouse erythropoiesis” in BLOOD, in collaboration with the laboratory of Mitchell Weiss, St. Jude Children’s Research Hospital.

Presentation at ASH

Patrick Somers, Research Specialist, presents a poster at the American Society of Hematology Annual Meeting 2019.