News
2026
Talk at the Penn Epigenetics Institute
Lucille Wang (Developmental, Stem Cell, and Regenerative Biology PhD student) gives a talk on using FIBER-Seq to profile ribosomal DNA chromatin states at the UPenn Epigenetics Seminar Series.
Talk at Genetics Research in Progress talks
Eleanor Sams (Genetics and Epigenetics PhD student) gives a talk on dynamics and manipulation of ribosomal RNA transcription in mouse hematopoiesis at Friday Genetics Research in Progress talk series organized by the Cell and Molecular Biology Genetics and Epigenetics Graduate Group.
Publication in Current Topics in Developmental Biology
Publication of “Ribosomal RNA transcription in normal and leukemic hematopoiesis” in CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY by co-first authors Jill Henrich and Eleanor Sams, PhD students in Cancer Biology and Genetics and Epigenetics respectively.
Talk at Penn Cancer Research Talks
Jill Henrich (Cancer Biology PhD student) gives a talk on control of ribosomal RNA transcription by MYC at the Penn Cancer Research talk series organized by the Cell and Molecular Biology (CAMB) Cancer Biology Graduate Group.
Poster Presentation at Penn CURF
Jolyn Heng and Dylan Dinh, UPenn undergraduate students, present posters at the Center for Undergraduate Research and Fellowships (CURF) Fall Research Expo on their work on the consequences of Pol I degradation in hematopoiesis.
Talk at the Penn Institute for RNA Innovation
Eleanor Sams (Genetics and Epigenetics PhD student) gives a talk on ribosomal RNA regulation in hematopoiesis and leukemia at the RNA & RNA Binding Proteins meeting at the Penn Institute for RNA Innovation.
Fellow promoted to Instructor
Putzer Hung, MD/PhD is promoted to Instructor in the Division of Hematology-Oncology, Department of Medicine. He is funded in this position by the Measey Scholars in Molecular Medicine Program.
Talk at MIT
Vikram Paralkar gives a talk on regulation of mammalian rRNA transcription at the Whitehead Institute and MIT. Many thanks to Yukiko Yamashita for the invitation.
Talk at Dana-Farber Cancer Institute
Vikram Paralkar gives a talk on rRNA transcription in hematopoiesis and leukemia at Hematological Malignancies Grand Rounds at the Dana-Farber Cancer Institute and Harvard University. Many thanks to Zuzana Tothova and Benson George for the invitation.
PhD student awarded NHLBI F31
Jill Henrich (Cancer Biology PhD student) is awarded an F31 grant by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to study the role of MYC in regulation of ribosomal RNA transcription in hematopoiesis.
Poster Presentations at Penn
Putzer Hung, MD/PhD (Hematology-Oncology fellow), Charles Antony, PhD (Research Associate), Jill Henrich (Cancer Biology PhD student), and Eleanor Sams (Genetics and Epigenetics PhD student) present posters on ribosomal RNA regulation in hematopoiesis and leukemia at the UPenn Department of Medicine Research Day 2026.
Hematology-Oncology fellow awarded grant
Putzer Hung, MD/PhD, Hematology-Oncology fellow, is selected as a Measey Scholar in Molecular Medicine by the Department of Medicine to study nucleolar targeting in acute myeloid leukemia.
Talk at Cincinnati Myeloid Workshop
Vikram Paralkar gives a talk on single molecule imaging of Pol I dynamics in leukemia at the Fifteenth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia organized by Cincinnati Children’s Hospital. Many thanks to Lee Grimes and Linde Miles.
Talk at the NIEHS
Vikram Paralkar visits the National Institute of Environmental Health Sciences (NIEHS) at the NIH and gives a talk on regulation of ribosomal RNA transcription. Many thanks to Dimitrios Theofilatos for the invitation.
Talk at the University of Wisconsin-Madison
Vikram Paralkar visits the University of Wisconsin-Madison and gives a talk on regulation of ribosomal RNA transcription in hematopoiesis and leukemia at the Carbone Cancer Center Oncology Grand Rounds. Many thanks to Emery Bresnick for the invitation.
Talks at the Hematology Research Training Program meeting
Putzer Hung (Hematology-Oncology fellow) and Jill Henrich (Cancer Biology PhD student) present talks about rRNA regulation in hematopoiesis and leukemia at the T32 Trainee Day for the Hematology Research Training Program.
Talk at the American Association for Cancer Research meeting
Putzer Hung, MD/PhD, Hematology-Oncology fellow, presents work at the 2026 AACR annual meeting on targeting rRNA transcription in acute myeloid leukemia. He is also an awardee of the 2025 AACR-John and Elizabeth Leonard Family Foundation Basic Cancer Research Fellowship.
Election to the ASCI
Vikram Paralkar is elected to the American Society for Clinical Investigation (ASCI). Many thanks to Ivan Maillard, Uli Steidl, Eirini Papapetrou, and Vijay Sankaran for the nomination.
Talk at Keystone Symposium
Jill Henrich (Cancer Biology PhD student) gives a talk on the role of MYC in regulating ribosomal RNA at the Keystone Symposium on Hematopoiesis. Eleanor Sams (Genetics and Epigenetics PhD student) presents a poster on quantification of nascent and mature ribosomal RNA in mouse hematopoiesis.
Talk at the Heme Malignancies Research in Progress meeting
Putzer Hung (Hematology-Oncology MD/PhD fellow), and Jill Henrich (Cancer Biology PhD student) present talks about ribosomal RNA regulation in leukemia at the University of Pennsylvania Heme Malignancies Research in Progress meeting.
Graduate student gives award lecture
Aishwarya Pawar, PhD (former Cancer Biology graduate student, currently postdoctoral fellow at University of Colorado, Anschutz) gives the award lecture for the 2025 Tom Kadesch Prize in Genetics.
Research Associate awarded ASH Scholar Award
Charles Antony, Postdoctoral Researcher, is awarded a Basic Research Fellow-to-Faculty Scholar Award by the American Society of Hematology.
2025
Talk at NIDDK PERFORM-KUH work-in-progress meeting
Eleanor Sams (Genetics and Epigenetics PhD student) gives a talk on quantification of nascent and mature ribosomal RNA in mouse hematopoiesis at the work-in-progress meeting for the PERFORM-KUH, Philadelphia’s NIDDK-sponsored U2C/TL1 research training program.
Chairing Scientific Committee at ASH
Vikram Paralkar chairs the Scientific Committee on Epigenetics and Genomics at the American Society of Hematology 2025 Annual Meeting in Orlando.
Talk and Poster Presentations at ASH
Vikram Paralkar presents a talk on single molecule visualization of RNA Polymerase I in hematopoiesis at the Scientific Workshop on Myeloid Development at the American Society of Hematology 2025 Annual Meeting in Orlando. Hematology-Oncology fellow Putzer Hung, recipient of an ASH Abstract Achievement Award, presents a poster on synergy of Pol I degradation with other therapies.
Talk at Penn Cancer Research Talks
Jill Henrich (Cancer Biology PhD student) gives a talk on quantification of regulation of ribosomal RNA transcription in AML by MYC at the Penn Cancer Research talk series organized by the Cell and Molecular Biology (CAMB) Cancer Biology Graduate Group.
Talk at the Penn Epigenetics Institute Retreat
Charles Antony (Research Associate) gives a talk, and CAMB PhD students Jill Henrich, Eleanor Sams, and recent PhD graduate Aishwarya Pawar present posters at the Penn Epigenetics Institute Annual Retreat at the University of Pennsylvania Perelman School of Medicine. Many thanks to Shelley Berger, Gerd Blobel, Golnaz Vahedi, and Colleen Blair.
Talk at Genetics Research in Progress talks
Eleanor Sams (Genetics and Epigenetics PhD student) gives a talk on quantification of nascent and mature ribosomal RNA in mouse hematopoiesis at Friday Genetics Research in Progress talk series organized by the Cell and Molecular Biology Genetics and Epigenetics Graduate Group.
Talk at NIDDK PERFORM-KUH retreat
Eleanor Sams (Genetics and Epigenetics PhD student) gives a talk on quantification of nascent and mature ribosomal RNA in mouse hematopoiesis at the annual retreat for the PERFORM-KUH, Philadelphia’s NIDDK-sponsored U2C/TL1 research training program.
Talk at Acute Leukemia Translational Research Meeting
Putzer Hung, MD/PhD, Hematology-Oncology fellow, presents a talk on ribosomal RNA transcription in human acute leukemia at the UPenn Acute Leukemia Translational Research Meeting.
Talk at the Penn Epigenetics Institute
Eleanor Sams (Genetics and Epigenetics PhD student) gives a talk on quantification of nascent and mature ribosomal RNA in mouse hematopoiesis at the UPenn Epigenetics Seminar Series.
Poster Presentation at Penn CURF
Rafael Nieto and Taejun Son, UPenn undergraduate students, present posters at the Center for Undergraduate Research and Fellowships (CURF) Fall Research Expo on their work on nucleolar regulation in hematopoiesis and leukemia.
Talk at EMBO Workshop on Ribosome Synthesis
Vikram Paralkar gives a talk on Pol I regulation at the EMBO Workshop “Ribosome Synthesis: from Mechanisms to Therapy” at the University of Cambridge, UK. Many thanks to Alan Warren and the organizers.
Talk at CSHL Mechanisms of Eukaryotic Transcription meeting
Vikram Paralkar gives a talk on Pol I regulation at the “Mechanisms of Eukaryotic Transcription” meeting at Cold Spring Harbor Laboratory, New York. Many thanks to Eva Nogales, Wendy Bickmore, and Joanna Wysocka.
Graduate student awarded Tom Kadesch Prize in Genetics
Aishwarya Pawar, PhD (Graduate Student in the Cancer Biology Program of the Cell and Molecular Biology Graduate Group at Penn) is awarded the Tom Kadesch Prize in Genetics. The award, in honor of Dr. Tom Kadesch, is given annually by the Department of Genetics to a graduate student demonstrating excellence in research achievement and citizenship.
Publication in Genes and Development
Publication of “Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness” in GENES & DEVELOPMENT by Aishwarya Pawar, Cancer Biology PhD student, as first author, and with contributions from Patrick Somers, Aleena Alex, Jason Grana, Victoria Feist, Subin George, Sapana Jalnapurkar, Charles Antony, Roman Verner, and Mohit Khera from the Paralkar Lab. Invaluable collaborative contributions were provided by Sandeep Gurbuxani (University of Chicago Department of Pathology), Jennifer Morrissette and Sanese White-Brown (UPenn Center for Personalized Diagnostics), and Kathy Liu and María Mendoza-Figueroa (UPenn Department of Biochemistry and Biophysics).
Poster at FASEB Hematologic Malignancies Conference
Charles Antony, Research Associate, presents a poster and gives a lightning talk on the role of CEBPA on regulation of Pol I at the FASEB Hematologic Malignancies conference at Southbridge, MA.
Talk at London RNA Club
Vikram Paralkar gives a talk at the “RNA in Cancer” symposium organized by the London RNA Club at Queen Mary University of London. Many thanks to Diu Nguyen for the invitation.
Grant from National Institutes of Health
The Paralkar Lab is awarded a renewal of a MIRA R35 grant by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) to study the regulation of ribosomal RNA transcription in mammalian tissues.
Undergraduate student begins medical school
Aleena Alex, undergraduate student in the University of Pennsylvania ’24 class, and recipient of the Ernest M Brown Jr Research Grant and the FERBS Scholarship, begins medical school at Indiana University School of Medicine. As a work-study student in the Paralkar lab, Aleena worked on modeling the molecular consequences of PHF6 mutations.
Cancer Biology graduate student defends thesis
Aishwarya Pawar, PhD (Graduate Student in the Cancer Biology Program of the Cell and Molecular Biology Graduate Group at Penn) defends her thesis on identification of a novel PHF6-PHIP chromatin complex that represses acute myeloid leukemia stemness. Many thanks to Nancy Speck for chairing Aishwarya’s thesis committee, and to Kathrin Bernt, Liling Wan, and Alessandro Gardini for their guidance on the committee.
Talk at Penn/CHOP Symposium
Vikram Paralkar gives a talk at the ACC Heme Malignancies Program/CHOP Research Institute Normal and Malignant Hematopoiesis Research Affinity Group Annual Joint Retreat. Many thanks to Carolyn Felix, Nancy Speck, and Ed Stadtmauer for the invitation.
Talk at Yale University School of Medicine
Vikram Paralkar gives a virtual talk to the NIDDK-sponsored U54 Yale Cooperative Center of Excellence in Hematology (YCCEH) “Rising Stars in Non-Malignant Hematology” Seminar Series. Many thanks to Diane Krause for the invitation.
Hematology-Oncology fellow awarded grant
Putzer Hung, MD/PhD, Hematology-Oncology fellow, is awarded the 2025 AACR-John and Elizabeth Leonard Family Foundation Basic Cancer Research Fellowship from the American Association for Cancer Research to study rRNA synthesis in acute myeloid leukemia.
Research Specialist begins PhD at Harvard
Victoria Feist (Research Specialist) begins her PhD in the Graduate Program in Biology and Biomedical Sciences at Harvard Medical School.
Talk at Gordon Research Conference on Red Cells
Vikram Paralkar gives a talk on rRNA transcription in hematopoiesis at the Gordon Research Conference on Red Cells at Salve Regina University, RI. Many thanks to Emery Bresnick and Laurie Steiner for the invitation.
Research Associate awarded Austrian Basic Science Award
Charles Antony, PhD (Research Associate) is awarded the ‘Austrian Basic Science Award by a Fellow’ by the Department of Medicine for his research on regulation of Polymerase I in hematopoiesis. The award is given each year at the Department of Medicine Research Day in memory of Robert Austrian, MD (1916-2007), who developed the pneumococcal pneumonia vaccine.
Poster Presentations at Penn
Charles Antony, PhD (Research Associate) and Victoria Feist (Research Specialist) present posters on transcriptional and ribosome biogenesis regulation in hematopoiesis and leukemia at the UPenn Department of Medicine Research Day 2025.
Talk at Albert Einstein College of Medicine
Vikram Paralkar gives a virtual talk to the Department of Cell Biology at the Albert Einstein College of Medicine. Many thanks to Kristy Stengel for the invitation.
Talk at the Hematology-Oncology Fellowship Meeting
Putzer Hung (Hematology-Oncology fellow) presents a talk about rRNA dependency in acute myeloid leukemia at the Hematology-Oncology Fellow Research Day.
Talk at Memorial Sloan Kettering Cancer Center
Vikram Paralkar gives a virtual talk on ribosomal RNA regulation in leukemia at Hematology Grand Rounds at the Memorial Sloan Kettering Cancer Center. Many thanks to Ivan Maillard for the invitation.
Talk at the Hematology Research Training Program meeting
Putzer Hung (Hematology-Oncology fellow) presents a talk about rRNA dependency in acute myeloid leukemia at the T32 Trainee Day for the Hematology Research Training Program.
Talk at PennVet Student Research Day
John Bullock (PennVet student) is awarded the Richard O. Davies Award for his talk on using single-cell RNA-Seq datasets to identify regulators of ribosomal RNA levels in human hematopoiesis.
Talk at Ohio State University
Vikram Paralkar gives a talk on control of ribosomal RNA transcription in mammalian cells at the Center for RNA Biology at Ohio State University. Many thanks to Mike Kearse for the invitation.
Talk at University of Washington
Vikram Paralkar gives a virtual talk on control of ribosomal RNA transcription in hematopoiesis and leukemia at the University of Washington Hematology Grand Rounds and Fred Hutch Cancer Center. Many thanks to Sergei Doulatov for the invitation.
Talk at Harvard University
Vikram Paralkar gives a talk on rRNA transcription in hematopoiesis and leukemia at Harvard Medical School and Boston Children’s Hospital. Many thanks to Grant Rowe for the invitation.
Talk at the Heme Malignancies Research in Progress meeting
Eleanor Sams (Genetics and Epigenetics PhD student), Charles Antony (Research Associate), and Santosh Adhikari (Postdoctoral fellow, Mustafa Mir lab, UPenn) present collaborative talks about ribosomal RNA regulation at the University of Pennsylvania Heme Malignancies Research in Progress meeting.
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2024
Oral and Poster Presentations at ASH
Research Associate Charles Antony, and PhD Candidates Aishwarya Pawar and Eleanor Sams, present talks on ribosomal RNA transcription and chromatin regulation in normal and leukemic hematopoiesis at the American Society of Hematology 2024 Annual Meeting in San Diego. All three are recipients of ASH Abstract Achievement Awards.
Award from UPenn Abramson Cancer Center
The Paralkar Lab is awarded an ACC Abramson Research Fellowship Award to study transcriptional regulation in acute leukemia.
Talk at the Penn Epigenetics Institute
Vikram Paralkar gives a talk on ribosomal RNA regulation in mammalian cells to the UPenn Epigenetics Seminar Series. Many thanks to Shelley Berger, Gerd Blobel, and Golnaz Vahedi.
Talk at University of Oxford
Vikram Paralkar gives a talk on ribosomal RNA regulation in hematopoiesis and leukemia at the Weatherall Institute of Molecular Medicine at the University of Oxford, UK. Many thanks to Paresh Vyas for the invitation.
Talk at EMBL Heidelberg
Vikram Paralkar gives a talk on ribosomal RNA regulation and Pol I biology to the Molecular Systems Biology group at EMBL Heidelberg, Germany. Many thanks to Christoph Müller for the invitation.
Postdoctoral grant from Abramson Family Cancer Research Institute
Charles Antony, Research Associate, is awarded an Abramson Family Cancer Research Institute Postdoctoral Fellowship to study regulation of rRNA transcription in acute myeloid leukemia by the transcription factor CEBPA.
Grant from National Institutes of Health
The Paralkar Lab is awarded an R21 grant by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to develop bioinformatic tools and datasets to study regulation of ribosomal DNA in hematopoiesis.
Publication in Leukemia
Publication of “PHF6 suppresses self-renewal of leukemic stem cells in AML” in LEUKEMIA by Sapana Jalnapurkar, PhD (postdoctoral fellow) and Aishwarya Pawar (PhD student) as co-first authors, with contributions from Subin George, Charles Antony, Patrick Somers, Jason Grana, Victoria Feist from the Paralkar Lab, in collaboration with Sandeep Gurbuxani from the University of Chicago.
Research Associate awarded Rising Star award
Charles Antony, PhD, Research Associate, is awarded the Rising Star Award and gives a talk at the Abramson Cancer Center Heme Malignancies Program/CHOP Research Institute Normal and Malignant Hematopoiesis Research Affinity Group Joint Retreat on his Molecular Cell publication on the regulation of rRNA transcription in myeloid progenitors.
Poster Presentations at Penn
Victoria Feist (Research Specialist), Charles Antony, PhD (Research Associate), and Subin George, MS (Computational Biologist) present posters on transcriptional and ribosome biogenesis regulation in hematopoiesis and leukemia at the UPenn Department of Medicine Research Day 2024.
Talk at FASEB Nuclear Bodies Conference
Vikram Paralkar and Charles Antony, Research Associate, give talks on rRNA regulation, Pol I imaging, and nucleolar biology at the FASEB Nuclear Bodies conference at Niagara Falls, NY.
Hematology-Oncology fellow awarded fellowship grant
Putzer Hung, MD/PhD, Hematology-Oncology fellow, is awarded the 2024 Marlene Shlomchik Fellowship in Cancer Research from the University of Pennsylvania Abramson Cancer Center to study rRNA transcription and the rDNA-associated proteome in leukemia.
Talk at Cincinnati Myeloid Workshop
Vikram Paralkar gives a talk on rRNA transcription in hematopoiesis at the Fourteenth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia organized by Cincinnati Children’s Hospital. Many thanks to Lee Grimes for the invitation.
Graduate Student Awarded Penn Global Citizenship Award
Aishwarya Pawar, PhD student, is awarded the 2024 Penn Global Citizenship Award. The Award recognizes individuals who have demonstrated a strong commitment to global engagement and exemplified the spirit of global citizenship during their time at Penn.
Talk at Penn Cell and Developmental Biology Retreat
Aishwarya Pawar, Cancer Biology PhD student, presents a talk on chromatin regulation in leukemia, and Charles Antony, Research Associate, presents a poster on rRNA transcription at the Cell and Developmental Biology Departmental Retreat for the University of Pennsylvania Perelman School of Medicine.
Talk at Columbia University
Vikram Paralkar gives a talk on ribosomal RNA regulation in hematopoiesis to the Department of Genetics & Development at the Columbia University Irving Medical Center. Many thanks to Aaron Viny for the invitation.
Talk at St. Jude Transcriptopathy conference
Vikram Paralkar gives a talk on ribosomal RNA transcriptional regulation in hematopoiesis and leukemia at the St. Jude Children’s Research Hospital Transcriptopathy conference at Key Largo, Florida. Many thanks to organizers Marcin Wlodarski, John Crispino, and Kim Nichols.
Publication in Current Opinion in Hematology
Publication of review article ‘Transcription factor regulation of ribosomal RNA in hematopoiesis’ in CURRENT OPINION IN HEMATOLOGY.
Talk at the Heme Malignancies Research in Progress meeting
Charles Antony (Research Associate), Eleanor Sams (Genetics and Epigenetics PhD student), and Victoria Feist (Research Specialist) present talks about ribosomal RNA regulation at the University of Pennsylvania Heme Malignancies Research in Progress meeting.
Grant from the Abramson Cancer Center
The Paralkar Lab is awarded a Pilot Research Grant by the Abramson Cancer Center to model AML evolution from germline Runx1 mutations. This grant is in collaboration with the laboratory of Nancy Speck, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine.
2023
Grant from National Institutes of Health
Charles Antony, Postdoctoral Researcher, is awarded a Co-Operative Center for Excellence in Hematology (CCEH) Type B grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) to study transcription factor dynamics and regulation in primary human bone marrow.
Poster presentation at CAMB symposium
Aishwarya Pawar, PhD student, presents a poster at the Cell and Molecular Biology Graduate Group Symposium 2023 on regulation of leukemia stemness by the chromatin factor PHF6.
Equipment award from National Institutes of Health
The Paralkar Lab is awarded an equipment award by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) to purchase a dedicated Sony benchtop SH800 cell flow sorter.
Talk at CAMB Penn Cancer Research Series
Charles Antony, Postdoctoral Researcher, presents a talk on rRNA regulation in hematopoiesis to the Cell and Molecular Biology Graduate Group at the University of Pennsylvania Perelman School of Medicine.
Poster Presentation at Penn CURF
Aleena Alex, UPenn undergraduate student, presents a poster at the Center for Undergraduate Research and Fellowships (CURF) Fall Research Expo on her work on PHD domain point mutations in chromatin regulators in leukemia.
Poster Presentations at ISEH
Postdoctoral Researcher Charles Antony and graduate student Aishwarya Pawar present posters of their work on chromatin and rRNA transcription regulation in hematopoiesis and leukemia at the International Society for Experimental Hematology 2023 Annual Meeting in New York.
Talk at FASEB Hematological Malignancies Conference
Vikram Paralkar gives a talk on the role of CEBPA in rRNA transcriptional regulation in hematopoiesis and leukemia at the FASEB Hematological Malignancies Conference at Southbridge, Massachusetts. Many thanks to organizers Britta Will and Alejandro Gutierrez.
Publication in STAR Protocols
Publication of “FISH-Flow to quantify nascent and mature ribosomal RNA in mouse and human cells” in STAR PROTOCOLS by Charles Antony, Patrick Somers, and Erin Gray in the Paralkar Lab.
Talk at the Penn Epigenetics Institute
Charles Antony, Postdoctoral Researcher, presents a talk on rDNA and rRNA regulation to the Penn Epigenetics Institute at the University of Pennsylvania Perelman School of Medicine.
Publication in the Journal of Biological Chemistry
Publication of “Construction and validation of customized genomes for human and mouse ribosomal DNA mapping” in JOURNAL OF BIOLOGICAL CHEMISTRY by Subin George in the Paralkar Lab.
Talk at the Fragile Nucleosome Seminar
Vikram Paralkar gives a talk on rRNA transcriptional regulation at the Fragile Nucleosome Seminar series. Many thanks to Ben Martin and team for organizing this forum and series of talks.
Talk at the RNA Polymerases 2023 conference
Vikram Paralkar gives a talk at International Conference on Transcriptional Regulation and Regulation by Archaeal, Plant and Eukaryotic Polymerases at the University of Jaén, Spain. Many thanks to Jorge Perez-Fernandez for the meeting and hospitality.
Talk at University of Michigan
Vikram Paralkar gives a talk on hematopoietic and leukemic transcriptional regulation to the University of Michigan Division of Hematology-Oncology. Many thanks to Shannon Carty for the invitation.
Talk at CAMB Penn Cancer Research Series
Charles Antony, Postdoctoral Researcher, presents a talk on rRNA regulation in hematopoiesis and leukemia to the Cell and Molecular Biology Graduate Group at the University of Pennsylvania Perelman School of Medicine.
Talk at CAMB Penn Cancer Research Series
Aishwarya Pawar, PhD student, presents a talk on chromatin regulator mutations in acute myeloid leukemia to the Cell and Molecular Biology Graduate Group at the University of Pennsylvania Perelman School of Medicine.
2022
Poster Presentations at ASH
Postdoctoral Researchers Sapana Jalnapurkar (ASH Restart Award recipient) and Charles Antony (ASH Scholar Award recipient) present posters of their work on chromatin and rRNA transcription regulation in hematopoiesis and leukemia at the American Society of Hematology 2022 Annual Meeting in New Orleans.
Undergraduate Student Awarded Research Grant
Aleena Alex, UPenn undergraduate student, is awarded the Center for Undergraduate Research and Fellowships (CURF) Award to study PHD domain point mutations in chromatin regulators in leukemia.
Publication in Molecular Cell
Publication of “Control of ribosomal RNA synthesis by hematopoietic transcription factors” in MOLECULAR CELL by Charles Antony, Postdoctoral Researcher, as first author, and with contributions from Subin George, Justin Blum, Patrick Somers, Chelsea Thorsheim, and Dexter Wu-Corts from the Paralkar Lab.
Graduate Student Awarded Best Poster Presentation
Aishwarya Pawar, PhD student, is awarded the Best Poster Presentation for Cancer Biology at the Cell and Molecular Biology Graduate Group Symposium 2022 for her presentation on chromatin occupancy and regulation by PHF6 in leukemia.
Talks at UPenn Heme Malignancies Research in Progress meeting
Sapana Jalnapurkar, Postdoctoral Researcher, and Aishwarya Pawar, PhD Student, present talks on work in mouse and human cell line models on the role of the chromatin regulator PHF6 in leukemia at the UPenn Heme Malignancies Research in Progress meeting.
Grant from Abramson Family Cancer Research Institute
The Paralkar Lab is awarded a Pilot Research Grant by the Abramson Family Cancer Research Institute to perform a CRISPR tiling mutagenesis screen to dissect ribosome biogenesis regulation in leukemia. This grant is in collaboration with the laboratory of Junwei Shi, Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine.
Collaborative publication in Blood Cancer Discovery
Publication by laboratory of Stuart Orkin and Max Pimkin of “Transcriptional Plasticity Drives Leukemia Immune Escape” in BLOOD CANCER DISCOVERY, with contribution from Paralkar Lab.
Talk at Penn and CHOP Retreat
Vikram Paralkar gives a talk on ribosome biogenesis in leukemia at the Penn and CHOP Hematological Malignancies Program Annual Retreat.
Talk at FASEB Nuclear Bodies Conference
Vikram Paralkar gives a talk on nucleolar biology in hematopoiesis and leukemia at the FASEB Nuclear Bodies conference at Nova Scotia, Canada.
Poster Presentations at Penn
Aishwarya Pawar, Ph.D. student, and Charles Antony, Postdoctoral Researcher, present posters on transcriptional and ribosome biogenesis regulation in hematopoiesis and leukemia at the UPenn Department of Medicine Research Day 2022.
Talk at University of Colorado
Vikram Paralkar visits the University of Colorado Anschutz Medical Campus and gives a talk on ribosomal regulation in hematopoiesis. Many thanks to Patricia Ernst for the invitation.
Talk at Penn Cell and Developmental Biology Retreat
Charles Antony, Postdoctoral Researcher, presents a talk on regulation of rRNA transcription by CEBPA at the Cell and Developmental Biology Departmental Retreat for the University of Pennsylvania Perelman School of Medicine.
Talk at University of California, San Diego
Vikram Paralkar pays a virtual visit to the University of California, San Diego (UCSD), and gives a talk to the Division of Regenerative Medicine on transcriptional regulation in hematopoiesis. Many thanks to Rob Signer for the invitation.
Collaborative publication in Genes and Development
Publication by laboratory of Stuart Orkin and Max Pimkin of “A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia” in GENES & DEVELOPMENT, with contribution from Paralkar Lab.
2021
Talks and Poster Presentations at ASH
Vikram Paralkar gives a talk at the Scientific Workshop on Myeloid Development at the American Society of Hematology Annual Meeting 2021. Charles Antony, Postdoctoral Researcher, and Aishwarya Pawar, PhD Student, present posters on rRNA transcription and chromatin regulation in leukemia.
Postdoctoral Researcher awarded ASH Scholar Award
Charles Antony, Postdoctoral Researcher, is awarded a Basic Research Fellow Scholar Award by the American Society of Hematology.
Talk at ASBMB conference
Vikram Paralkar gives a talk at the American Society for Biochemistry and Molecular Biology (ASBMB) conference on Emerging roles of the nucleolus.
Postdoctoral Researcher awarded ASH Restart Award
Sapana Jalnapurkar, Postdoctoral Researcher, is awarded a Research Restart Award by the American Society of Hematology.
Talk at FASEB meeting
Vikram Paralkar gives a talk on the role of CEBPA in ribosomal RNA regulation at the FASEB Hematological Malignancies Conference.
Collaborative Publication in Cell Stem Cell
Laboratory of Wei Tong, Children’s Hospital of Philadelphia, publishes “HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis” in CELL STEM CELL with contribution from Charles Antony and Vikram Paralkar from the Paralkar Lab.
Poster Presentations at Penn
Charles Antony and Sapana Jalnapurkar, Postdoctoral Researchers, present posters on ribosomal RNA regulation and leukemia mouse models at the University of Pennsylvania Department of Medicine Research Day 2021.
Talk at Keystone Symposium
Vikram Paralkar gives a talk on the role of transcription factors in regulating ribosomal RNA at the Keystone Symposium on Hematopoiesis.
Talk at the Heme Malignancies Research in Progress meeting
Charles Antony, Postdoctoral Researcher, presents a talk about work on transcriptional regulation of ribosomal RNA at the University of Pennsylvania Heme Malignancies Research in Progress meeting.
Grant from National Institutes of Health
The Paralkar Lab is awarded a Co-Operative Center for Excellence in Hematology (CCEH) grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) to model the effect of RUNX1 point mutations on mouse hematopoietic stem and progenitor cells.
2020
Grant from National Institutes of Health
The Paralkar Lab is awarded an R01 grant by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to study the role of the chromatin binding and nucleolar protein PHF6 in the regulation of HSC self-renewal and myeloid differentiation.
Presentations at ASH
Sapana Jalnapurkar and Charles Antony, Postdoctoral Researchers, present oral talk and poster presentation respectively at the American Society of Hematology Annual Meeting 2020.
Grant from National Institutes of Health
The Paralkar Lab is awarded a MIRA R35 grant by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) to study the regulation of ribosomal RNA transcription in mammalian tissues.
Poster Presentations at Penn
Sapana Jalnapurkar and Charles Antony, Postdoctoral Researchers, present posters at the University of Pennsylvania Department of Medicine Research Day 2020.
2019
Grant from American Cancer Society
The Paralkar Lab receives funding through the American Cancer Society Institutional Research Grant to study the role of PHF6 in acute myeloid leukemia.
Publication in Blood
The Paralkar Lab publishes “Regulation of gene expression by miR-144/451 during mouse erythropoiesis” in BLOOD, in collaboration with the laboratory of Mitchell Weiss, St. Jude Children’s Research Hospital.
2018
Presentation at ASH
Patrick Somers, Research Specialist, presents a poster at the American Society of Hematology Annual Meeting 2018.