Paralkar Lab · Penn Medicine ·
Penn Epigenetics Institute
The cell's busiest factory is its least understood.
Inside the nucleolus, RNA Polymerase I transcribes the ribosomal RNAs at the heart of every ribosome. We study how this ribosome factory guides normal hematopoiesis and immunity, and fuels leukemia.
Research
The control knob
How does a cell set the pace of its ribosome factory?
The consequences
Why do different blood cells need different numbers of ribosomes?
The disease
How does leukemia hijack the ribosome factory, and can we selectively repress it?
The Paralkar Lab is in the Division of Hematology-Oncology in the University of Pennsylvania Perelman School of Medicine, and is affiliated with the Penn Epigenetics Institute, the Department of Cell and Developmental Biology, the Abramson Family Cancer Research Institute, and the Abramson Cancer Center.
Funding
